abstract：OBJECTIVE:To quantify the current national burden of opioids for osteoarthritis (OA) pain in Australia in terms of number of dispensed opioid prescriptions and associated costs, and to forecast the likely burden to the year 2030/31. DESIGN:Epidemiological modelling. METHODS:Published data were obtained on rates of op...

journal_title：Osteoarthritis and cartilage

authors： Ackerman IN,Zomer E,Gilmartin-Thomas JF,Liew D

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate the ability of full-field optical coherence tomography (FFOCT) to qualitatively and quantitatively evaluate cartilage degeneration using the qualitative evaluation of histology sections as the reference. DESIGN:Thirty-three human knee cartilage samples of variable...

journal_title：Osteoarthritis and cartilage

authors： Pailhé R,Mounier A,Boisson B,Rouchy RC,Voros S,Chipon E,Boudry I,Medici M,Hughes C,Moreau-Gaudry A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABT-981, a human dual variable domain immunoglobulin simultaneously targeting interleukin (IL)-1α and IL-1β, in patients with knee osteoarthritis (OA). METHOD:This was a randomized, double-blind, placebo-controlled, single-cen...

journal_title：Osteoarthritis and cartilage

authors： Wang SX,Abramson SB,Attur M,Karsdal MA,Preston RA,Lozada CJ,Kosloski MP,Hong F,Jiang P,Saltarelli MJ,Hendrickson BA,Medema JK

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading...

journal_title：Osteoarthritis and cartilage

authors： Adebayo OO,Ko FC,Wan PT,Goldring SR,Goldring MB,Wright TM,van der Meulen MCH

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Solutes and interstitial water are naturally transported from cartilage by load-induced interstitial fluid pressures. Fluid and solute recovery during joint articulation have been primarily attributed to passive diffusion and mechanical 'pumping' from dynamic loading. This paper tests if the sliding action of...

journal_title：Osteoarthritis and cartilage

authors： Graham BT,Moore AC,Burris DL,Price C

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:In this population-based cohort study, we examined the association between the presence of symptomatic osteoarthritis (OA) and risk for cardiovascular (CV) events. METHOD:A cohort aged ≥55 years recruited from 1996 to 98 was followed through provincial health administrative data to 2014. Demographics, joint ...

journal_title：Osteoarthritis and cartilage

authors： Kendzerska T,Jüni P,King LK,Croxford R,Stanaitis I,Hawker GA

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:We aimed to (1) determine reference values for trochlear morphology and patellofemoral (PF) alignment in adults without magnetic resonance imaging (MRI)-defined PF full thickness cartilage damage or knee pain; and (2) evaluate dose-response patterns for these measures with prevalent MRI-defined PF structural ...

journal_title：Osteoarthritis and cartilage

authors： Macri EM,Felson DT,Zhang Y,Guermazi A,Roemer FW,Crossley KM,Khan KM,Stefanik JJ

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To explore effects of weight loss and maintenance on serum cartilage biomarkers denaturation neoepitope for Collagen2 (Coll2-1) and Fibulin3 fragment (Fib3-2), as well as correlations between Coll2-1 and Fib3-2 and symptomatic improvement, in a knee osteoarthritis (KOA) population. DESIGN:192 obese KOA patie...

journal_title：Osteoarthritis and cartilage

authors： Bartels EM,Henrotin Y,Bliddal H,Centonze P,Henriksen M

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Prospectively monitor how treatment of acutely ruptured anterior cruciate ligament (ACL) affects biomarkers of inflammation and proteolytic degradation over 5 years. DESIGN:We studied 119 subjects with acute ACL injury from the randomized controlled knee anterior cruciate ligament, non-surgical versus surgic...

journal_title：Osteoarthritis and cartilage

authors： Larsson S,Struglics A,Lohmander LS,Frobell R

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:This study is to investigate the functions and underlying mechanisms of mesenchymal stem cells (MSCs) underwent stepwise preconditioning in chondrogenic medium before expansion, then further explore their therapeutic effects in a surgically induced osteoarthritis (OA) model. METHODS:MSCs isolated from the ad...

journal_title：Osteoarthritis and cartilage

authors： Lin S,Lee WYW,Xu L,Wang Y,Chen Y,Ho KKW,Qin L,Jiang X,Cui L,Li G

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To examine the clinical impact of coexisting lateral osteoarthritis (OA) in knees with mild medial OA. DESIGN:In patients with Kellgren/Lawrence (K/L) grade 2 OA in the medial compartment (n = 100; age: 56-89 years; 80.0% female), anteroposterior knee radiography was used to assess the presence of lateral OA...

journal_title：Osteoarthritis and cartilage

authors： Iijima H,Aoyama T,Nishitani K,Ito H,Fukutani N,Isho T,Kaneda E,Kuroki H,Matsuda S

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:A recent genome-wide association study reported significant associations of genetic variants within the ALDH1A2 gene with osteoarthritis (OA) of the hand in European populations. However, these findings have not been well generalized to other joints, or to other populations. METHODS:We performed a two-stage ...

journal_title：Osteoarthritis and cartilage

authors： Chu M,Zhu X,Wang C,Rong J,Wang Y,Wang S,Xing B,Tao Y,Zhuang X,Jiang L

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is associated with increased articular cartilage hydraulic permeability and decreased maintenance of high interstitial fluid load support (IFLS) during articulation, resulting in increased friction on the cartilage solid matrix. This study assesses frictional response following in situ syn...

journal_title：Osteoarthritis and cartilage

authors： Cooper BG,Lawson TB,Snyder BD,Grinstaff MW

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for devel...

journal_title：Osteoarthritis and cartilage

authors： Yang CY,Chanalaris A,Troeberg L

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Autotaxin is a secreted lysophospholipase that mediates the conversion of lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA), a bioactive lipid mediator. Autotaxin levels in plasma and synovial fluid correlate with disease severity in patients with knee osteoarthritis (OA). The goal of this study w...

journal_title：Osteoarthritis and cartilage

authors： Thirunavukkarasu K,Swearingen CA,Oskins JL,Lin C,Bui HH,Jones SB,Pfeifer LA,Norman BH,Mitchell PG,Chambers MG

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To determine the association of varus thrust during walking to incident and worsening medial tibiofemoral cartilage damage and bone marrow lesions (BMLs) over 2 years in older adults with or at risk for osteoarthritis (OA). METHOD:Subjects from the Multicenter Osteoarthritis Study (MOST) were studied. Varus ...

journal_title：Osteoarthritis and cartilage

authors： Wink AE,Gross KD,Brown CA,Guermazi A,Roemer F,Niu J,Torner J,Lewis CE,Nevitt MC,Tolstykh I,Sharma L,Felson DT

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To investigate the association between smoking and the risk for knee osteoarthritis (OA). DESIGN:Cohort, case-control, and cross-sectional studies were obtained from the Medline, Embase, and Web of Science databases. Estimates were calculated using a random-effects model. Subgroup analyses and meta-regressio...

journal_title：Osteoarthritis and cartilage

authors： Kong L,Wang L,Meng F,Cao J,Shen Y

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To determine the magnitude of medial femoral cartilage deformation using ultrasonography (US) following walking and running in healthy individuals. DESIGN:Twenty-five healthy participants with no history of osteoarthritis or knee injury volunteered for this study. Medial femoral cartilage thickness was asses...

journal_title：Osteoarthritis and cartilage

authors： Harkey MS,Blackburn JT,Davis H,Sierra-Arévalo L,Nissman D,Pietrosimone B

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Moderate mechanical stress generated by normal joint loading and movement is essential for the maintenance of healthy articular cartilage. However, the effects of reduced loading caused by the absence of weight bearing or joint motion on articular cartilage and subchondral bone is still poorly understood. We ...

journal_title：Osteoarthritis and cartilage

authors： Nomura M,Sakitani N,Iwasawa H,Kohara Y,Takano S,Wakimoto Y,Kuroki H,Moriyama H

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI) texture analysis is a method of analyzing subchondral bone alterations in osteoarthritis (OA). The objective of this study was to evaluate the association between MR texture analysis and ground-truth subchondral bone histomorphometry at the tibial plateau. DESIGN:The local re...

journal_title：Osteoarthritis and cartilage

authors： MacKay JW,Murray PJ,Kasmai B,Johnson G,Donell ST,Toms AP

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare the reliability of this approach with conventional arthroscopic scoring ex vivo. DESIGN:Areas of in...

journal_title：Osteoarthritis and cartilage

authors： Sarin JK,Brommer H,Argüelles D,Puhakka PH,Inkinen SI,Afara IO,Saarakkala S,Töyräs J

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:We aimed to determine the minimum mechanical impact to cause microstructural damage in the network of collagen (microcracking) within human cartilage and hypothesized that energies below 0.1 J or 1 mJ/mm3 would suffice. DESIGN:We completed 108 low-energy impact tests (0.05, 0.07, or 0.09 J; 0.75 or 1.0 m/s2)...

journal_title：Osteoarthritis and cartilage

authors： Kaleem B,Maier F,Drissi H,Pierce DM

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To correlate osteochondral repair assessed by validated macroscopic scoring systems with established semiquantitative histological analyses in an ovine model and to test the hypothesis that important macroscopic individual categories correlate with their corresponding histological counterparts. METHODS:In th...

journal_title：Osteoarthritis and cartilage

authors： Goebel L,Orth P,Cucchiarini M,Pape D,Madry H

更新日期：2017-04-01 00:00:00

abstract：:In this communication, we discuss some key issues surrounding the translation of preclinical efficacy studies in models of painful osteoarthritis (OA) to the clinical arena. We highlight potential pitfalls which could negatively impact successful translation. These include lack of alignment between a model + endpoint ...

journal_title：Osteoarthritis and cartilage

authors： Hummel M,Whiteside GT

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Lipocalin-2 (LCN2) is a recently characterized adipokine that is upregulated in chondrocytes treated with pro-inflammatory mediators and in the synovial fluid of osteoarthritis (OA) patients. Here, we explored the in vivo functions of LCN2 in OA cartilage destruction in mice. METHODS:The expression levels of...

journal_title：Osteoarthritis and cartilage

authors： Choi WS,Chun JS

更新日期：2017-03-01 00:00:00

abstract：:Inappropriate biomechanics, namely wear-and-tear, has been long believed to be a main cause of osteoarthritis (OA). However, this view is now being re-evaluated, especially when examined alongside mechanobiology and new biomechanical studies. These are multiscale experimental and computational studies focussing on cel...

journal_title：Osteoarthritis and cartilage

authors： Saxby DJ,Lloyd DG

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To validate simple criteria that distinguish flat flexible from stable supportive walking shoes by comparing their effects on the knee adduction moment (KAM) in people with medial knee osteoarthritis (OA). DESIGN:This was a cross-sectional biomechanical study. We proposed five criteria to differentiate flat ...

journal_title：Osteoarthritis and cartilage

authors： Paterson KL,Bennell KL,Wrigley TV,Metcalf BR,Kasza J,Hinman RS

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:During exercise, cartilage recovers interstitial fluid lost during inactivity, which explains how tissue thickness and joint space are maintained over time. This recovery phenomenon is currently explained by a combination of osmotic swelling during intermittent bath exposure and sub-ambient pressurization dur...

journal_title：Osteoarthritis and cartilage

authors： Moore AC,Burris DL

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Little is known about how static standing balance changes post total knee arthroplasty (TKA). The primary aim of this study was to examine the sensitivity to change and redundancy of center of pressure (COP) variables post-TKA. The secondary aim was to compare the sensitivity of these measures to standard cli...

journal_title：Osteoarthritis and cartilage

authors： Clark RA,Seah FJ,Chong HC,Poon CL,Tan JW,Mentiplay BF,Pua YH

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:To examine the effect of Osteoarthritis (OA)-related difficulty walking on risk for diabetes complications in persons with diabetes and OA. DESIGN:A population cohort aged 55+ years with symptomatic hip and knee OA was recruited 1996-98 and followed through provincial administrative data to 2015 (n = 2,225)...

journal_title：Osteoarthritis and cartilage

authors： Hawker GA,Croxford R,Bierman AS,Harvey P,Ravi B,Kendzerska T,Stanaitis I,King LK,Lipscombe L

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Based on the concept of a systemic predisposition for articular cartilage calcification (CC), the aim of this study was to determine the prevalence and amount of bilateral CC of hip and knee joints in an unselected sample cohort by high-resolution digital contact radiography (DCR) and to analyze the associat...

journal_title：Osteoarthritis and cartilage

authors： Hawellek T,Hubert J,Hischke S,Krause M,Bertrand J,Pap T,Püschel K,Rüther W,Niemeier A

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI). DESIGN:Seventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiogra...

journal_title：Osteoarthritis and cartilage

authors： Goldman LH,Tang K,Facchetti L,Heilmeier U,Joseph GB,Nevitt MC,McCulloch CE,Souza RB,Link TM

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:To address the hypothesis that different types of established osteoarthritis (OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosod...

journal_title：Osteoarthritis and cartilage

authors： Nwosu LN,Mapp PI,Chapman V,Walsh DA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Polyacrylamide hydrogel (PAAG) is a non-toxic, non-degradable synthetic product, used for years in the augmentation of soft tissues. Preliminary results in animals and humans have suggested long-lasting beneficial effects on symptoms of osteoarthritis (OA). The aim of this histopathological study was to inves...

journal_title：Osteoarthritis and cartilage

authors： Christensen L,Camitz L,Illigen KE,Hansen M,Sarvaa R,Conaghan PG

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:The optimal therapy for femoroacetabular impingement (FAI) is unclear. The aim of this systematic review was to examine the evidence for surgical and non-surgical treatment of FAI on symptom and structural outcomes. DESIGN:MEDLINE and EMBASE were searched electronically. Surgical and non-surgical management ...

journal_title：Osteoarthritis and cartilage

authors： Fairley J,Wang Y,Teichtahl AJ,Seneviwickrama M,Wluka AE,Brady SRE,Hussain SM,Liew S,Cicuttini FM

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Emerging evidence suggests that diabetes may be a risk factor for osteoarthritis (OA). However, previous results on the association between diabetes and all OA were conflicting. We aimed to comprehensively analyse the association between type II diabetes mellitus (T2DM) and osteoarthritis of the hand (HOA) s...

journal_title：Osteoarthritis and cartilage

authors： Frey N,Hügle T,Jick SS,Meier CR,Spoendlin J

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms contributing to the a...

journal_title：Osteoarthritis and cartilage

authors： Xu L,Nwosu LN,Burston JJ,Millns PJ,Sagar DR,Mapp PI,Meesawatsom P,Li L,Bennett AJ,Walsh DA,Chapman V

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:According to prevailing consensus, patients with mechanical symptoms are those considered to most likely benefit from arthroscopic surgery. The aim of this study was to determine the value of using patients' pre-operative self-reports of mechanical symptoms as a justification surgery in patients with degenera...

journal_title：Osteoarthritis and cartilage

authors： Sihvonen R,Englund M,Turkiewicz A,Järvinen TL

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. METHODS:3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of seve...

journal_title：Osteoarthritis and cartilage

authors： Gallo MC,Wyatt C,Pedoia V,Kumar D,Lee S,Nardo L,Link TM,Souza RB,Majumdar S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To compare the epigenetic landscape of 3D cell models of human primary articular chondrocytes (hPACs) and human bone-marrow derived mesenchymal stem cells (hBMSCs) and their respective autologous articular cartilage. DESIGN:Using Illumina Infinium HumanMethylation450 BeadChip arrays, the DNA methylation lan...

journal_title：Osteoarthritis and cartilage

authors： Bomer N,den Hollander W,Suchiman H,Houtman E,Slieker RC,Heijmans BT,Slagboom PE,Nelissen RG,Ramos YF,Meulenbelt I

更新日期：2016-08-01 00:00:00